Artificial Intelligence (AI) is at the heart of Cognitive Systems. The development of trustworthy cognitive systems therefore starts with trustworthy AI. Recent developments such as the European Union's AI Regulation show the increasing importance of developing strong AI solutions that society can trust. The Fraunhofer Institute for Cognitive Systems IKS focuses its research on aspects that are particularly relevant for cyber-physical systems. Therefore, we research approaches that have a direct impact on the reliability and safety of artificial intelligence for various application areas. These include autonomous driving, production, smart farming, medicine, and quantum computing.